The behavior of the boundary of generalized synchronization in two unidirectionally coupled chaotic oscillators depending on the value of the control parameter mismatch between interacting systems has been studied. Peculiarities in its behavior in the field of the relatively large values of the control parameter mistuning have been found. The character of this behavior and physical mechanisms resulting in the generalized synchronization regime onset in such systems have been explained by the analysis of the spectral compound of signal from response system.