Нефроны

Based on the wavelet­analysis of experimental data, we study in this paper the phenomenon of synchronization of oscillations in the dynamics of small groups of structural units of the kidney (paired nephrons and triplets). Distinctions between synchronous dynamics of interacting nephrons in normal and hypertensive rats are discussed. We show that mean duration of synchronous oscillations is about 3 times less in hypertensive rats. We state that in­phase synchronization is the most typical case in the dynamics of interacting nephrons (more than 90% of experimental data).

Based on the analysis of experimental data we study the collective dynamics of ensembles from several tens nephrons located on a kidney surface. Using wavelet­analysis, the phenomenon of locking of instantaneous frequencies and phases is studied that is caused by the tubulo­glomerular feedback. It is shown that structural units of the kidney related to distinct nephron trees participate in clusters formation. The entrainment of frequencies and phases of oscillations for large groups of nephrons occurs only for some fragments of experimental data.